Slc14a2 Gene Summary [Rat]
The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | Slc14a2 |
| Official Name | solute carrier family 14 member 2 [Source:RGD Symbol;Acc:3689] |
| Ensembl ID | ENSRNOG00000056021 |
| Bio databases IDs | |
| Aliases | solute carrier family 14 member 2 |
| Synonyms | HUT2, Rut, Slc14a2T, Slc14a2 v4, solute carrier family 14 member 2, solute carrier family 14 (urea transporter), member 2, testSymbol, UrT1-C, UrT1-D, UT2, UT-A, UT-A1, UTA3, UTR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc14a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- intracellular loop
- cell adhesion molecule binding
- urea transporter
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- Alzheimer disease
- breast carcinoma
- alopecia
- pericarditis
- progressive vision loss
- metabolic syndrome X
- non-insulin-dependent diabetes mellitus
- refractive error
- cardiac fibrosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- apical compartment
- cellular membrane
- vesicles
- apical membrane
- basolateral membrane
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc14a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- urea transport
- transmembrane transport
- urea transmembrane transport
Cellular Component
Where in the cell the gene product is active
- membrane
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cell adhesion molecule binding
- urea transmembrane transporter activity