Matn3 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Predicted to be involved in extracellular matrix organization. Predicted to act upstream of or within cartilage development. Predicted to be located in extracellular matrix. Predicted to be part of matrilin complex. Predicted to be active in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in multiple epiphyseal dysplasia 5; osteoarthritis; and osteochondrodysplasia. Orthologous to human MATN3 (matrilin 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Matn3 |
| Official Name | matrilin 3 [Source:RGD Symbol;Acc:1305085] |
| Ensembl ID | ENSRNOG00000056141 |
| Bio databases IDs | |
| Aliases | matrilin 3 |
| Synonyms | DIPOA, EDM5, HOA, matrilin-3, OADIP, OS2, SEMDBCD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Matn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Complement Clr-like EGF-like
- von Willebrand factor (vWF) type A domain
- Trimeric coiled-coil oligomerization domain of matrilin
- vWFA
- extracellular matrix structural constituent
- coiled-coil domain
- protein binding
- von Willebrand factor type A domain
- Coagulation Factor Xa inhibitory site
Pathways
Biological processes and signaling networks where the Matn3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- hereditary disorder
- multiple epiphyseal dysplasia 5
- hepatocellular carcinoma
- osteoarthritis susceptibility 2
- osteoarthritis
- spondyloepimetaphyseal dysplasia, matrilin-3 type
- autosomal dominant multiple epiphyseal dysplasia
- systemic sclerosis
role in cell
- replication in
- number
- diameter
- organization
- adhesion
- volume density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- interterritorial matrix
- cell-associated matrix
- endoplasmic reticulum lumen
- extracellular matrix
- territorial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Matn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal system development
- extracellular matrix organization
- cartilage development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- extracellular matrix structural constituent