Fbxo22 Gene Summary [Rat]
Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; and regulation of skeletal muscle fiber development. Predicted to act upstream of or within several processes, including nucleocytoplasmic transport; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of myotube differentiation. Predicted to be located in cytoplasm and nucleus. Orthologous to human FBXO22 (F-box protein 22). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo22 |
| Official Name | F-box protein 22 [Source:RGD Symbol;Acc:1306664] |
| Ensembl ID | ENSRNOG00000022702 |
| Bio databases IDs | |
| Aliases | F-box protein 22 |
| Synonyms | 0610033L19RIK, 1600016C16Rik, F-box protein 22, FBX22, FISTC1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fbxo22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- F-box domain superfamily
- ubiquitin-protein transferase activity
- F-box-like
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung adenocarcinoma
- neoplasia
- metastasis
- lung adenocarcinoma formation
- gout
- organismal death
- colitis
- neurodevelopmental disorder
- acute myeloid leukemia
role in cell
- apoptosis
- expression in
- differentiation
- binding in
- phosphorylation in
- invasion by
- degradation in
- ionizing radiation sensitivity
- radiosensitivity
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fbxo22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleocytoplasmic transport
- protein modification process
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of skeletal muscle fiber development
- protein polyubiquitination
- cellular response to starvation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding