Zdhhc18 Gene Summary [Rat]
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation; protein targeting to membrane; and regulation of innate immune response. Predicted to act upstream of or within protein localization. Predicted to be located in cytosol. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC18 (zinc finger DHHC-type palmitoyltransferase 18). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zdhhc18 |
| Official Name | zinc finger, DHHC-type containing 18 [Source:RGD Symbol;Acc:1309334] |
| Ensembl ID | ENSRNOG00000058156 |
| Bio databases IDs | |
| Aliases | zinc finger, DHHC-type containing 18 |
| Synonyms | DHHC-18, zinc finger, DHHC domain containing 18, zinc finger DHHC-type palmitoyltransferase 18 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zdhhc18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- protein-cysteine S-palmitoleyltransferase
- DHHC palmitoyltransferase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zdhhc18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- peptidyl-L-cysteine S-palmitoylation
- protein palmitoylation
- protein targeting to membrane
- negative regulation of innate immune response
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- Golgi membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- palmitoyltransferase activity