Asgr2 Gene Summary [Rat]
Predicted to enable D-mannose binding activity; fucose binding activity; and pattern recognition receptor activity. Involved in bone mineralization. Predicted to be located in endoplasmic reticulum quality control compartment and perinuclear region of cytoplasm. Predicted to be active in external side of plasma membrane. Orthologous to human ASGR2 (asialoglycoprotein receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asgr2 |
| Official Name | asialoglycoprotein receptor 2 [Source:RGD Symbol;Acc:2161] |
| Ensembl ID | ENSRNOG00000030726 |
| Bio databases IDs | |
| Aliases | asialoglycoprotein receptor 2 |
| Synonyms | ASGP-R, ASGP-R2, ASGPR H2B, Asgr, asialoglycoprotein receptor 2, CLEC4H2, HBXBP, HL-2, L-H2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Asgr2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hepatic lectin, N-terminal domain
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- cytoplasmic domain
- asialoglycoprotein receptor
- Lectin C-type domain
- protein binding
- EGF-like domain
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatoblastoma
- liver cancer
- Parkinson disease
- organismal death
- infection by Marburg virus
- infection by bacteria
role in cell
- expression in
- binding
- opsonization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- vesicles
- Endoplasmic Reticulum
- nucleosomes
- early endosomes
- membrane blebs
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Asgr2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interspecies interaction between organisms
- cell surface receptor signaling pathway
- endocytosis
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- external side of plasma membrane
- endoplasmic reticulum quality control compartment
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- mannose binding
- protein binding
- fucose binding
- asialoglycoprotein receptor activity