Triobp Gene Summary [Rat]
Predicted to enable actin filament binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of substrate adhesion-dependent cell spreading. Predicted to act upstream of or within auditory receptor cell stereocilium organization and sensory perception of sound. Predicted to be located in stereocilium base. Predicted to be active in actin cytoskeleton. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 28. Orthologous to human TRIOBP (TRIO and F-actin binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Triobp |
| Official Name | TRIO and F-actin binding protein [Source:RGD Symbol;Acc:1308485] |
| Ensembl ID | ENSRNOG00000059015 |
| Bio databases IDs | |
| Aliases | TRIO and F-actin binding protein |
| Synonyms | DFNB28, dJ37E16.4, EST478828, HRIHFB2122, mKIAA1662, Q5R3M6, TAP68, TARA, TRIO and F-actin binding protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Triobp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- ubiquitin protein ligase binding
- polo kinase kinase
- HAUS augmin-like complex subunit 3
- central domain
- coiled-coil domain
- protein binding
- Pleckstrin homology-like domain
- actin filament binding
- Transforming acidic coiled-coil-containing protein (TACC), C-terminal
- PH domain
- Intermediate filament protein
- Metaviral_G glycoprotein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive deafness type 28
- COVID-19
- glaucoma
- autosomal recessive nonsyndromic postlingual hearing loss
- covid-19 death
- age-related hearing loss
- hearing loss
- autosomal recessive deafness
- familial nonsyndromic hearing impairment
- pervasive developmental disorder
regulates
- actin
- F Actin
role in cell
- number
- formation
- formation in
- development
- depolymerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- actin cytoskeleton
- cytosol
- stereocilia
- ciliary rootlet
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Triobp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- auditory receptor cell stereocilium organization
- sensory perception of sound
- barbed-end actin filament capping
- positive regulation of substrate adhesion-dependent cell spreading
- actin modification
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- centrosome
- focal adhesion
- cytoplasm
- actin cytoskeleton
- midbody
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ubiquitin protein ligase binding
- myosin II binding
- small GTPase binding