Exoc6b Gene Summary [Rat]
Predicted to be involved in Golgi to plasma membrane transport and exocytosis. Predicted to be part of exocyst. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia with joint laxity type 3. Orthologous to human EXOC6B (exocyst complex component 6B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Exoc6b |
| Official Name | exocyst complex component 6B [Source:RGD Symbol;Acc:1560638] |
| Ensembl ID | ENSRNOG00000059615 |
| Bio databases IDs | |
| Aliases | exocyst complex component 6B |
| Synonyms | 4930569O18Rik, exocyst complex component 6B, G430127E12Rik, mKIAA0919, RGD1560638, SEC15B, SEC15L2, SEMDJL3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Exoc6b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Exocyst complex subunit Sec15-like
- protein binding
Pathways
Biological processes and signaling networks where the Exoc6b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- malaria
- non-insulin-dependent diabetes mellitus
- spondyloepimetaphyseal dysplasia with joint laxity type 3
- hereditary disorder
- non-small cell lung cancer
- colorectal cancer
- organismal death
- metastasis
- neuroblastoma
- neuroblastoma formation
role in cell
- migration
- expression in
- proliferation
- apoptosis
- invasion by
- heterodimerization in
- phosphorylation in
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Exoc6b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- cytokinesis after mitosis
- vesicle docking involved in exocytosis
- Golgi to plasma membrane transport
- intracellular protein transport
- exocytosis
Cellular Component
Where in the cell the gene product is active
- exocyst
Molecular Function
What the gene product does at the molecular level
- protein binding