Akap12 Gene Summary [Rat]
Predicted to enable adenylate cyclase binding activity. Involved in several processes, including cellular response to cytokine stimulus; hepatic stellate cell activation; and positive regulation of ERK1 and ERK2 cascade. Located in neuronal cell body. Biomarker of brain ischemia; liver cirrhosis; osteosarcoma; and sciatic neuropathy. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Akap12 |
| Official Name | A-kinase anchoring protein 12 [Source:RGD Symbol;Acc:70988] |
| Ensembl ID | ENSRNOG00000019549 |
| Bio databases IDs | |
| Aliases | A-kinase anchoring protein 12 |
| Synonyms | AKAP12A, AKAP12B, AKAP12G, AKAP250, A-kinase anchoring protein 12, A kinase anchor protein 12, Srcs5, SSECKS, Ssecks322, Tsga12 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Akap12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase A binding
- receptor signaling complex scaffold protein
- adenylate cyclase binding
- WSK motif
- Pkc binding domain
- protein binding
- cyclin-binding domain
- transporter
Pathways
Biological processes and signaling networks where the Akap12 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- peripheral arterial disease
- cutaneous melanoma
- hyperplasia
- male pattern hair loss
- acute myeloid leukemia
- infertility condition
- idiopathic pulmonary fibrosis
- prostatic intraepithelial neoplasia
- tumorigenesis
role in cell
- proliferation
- expression in
- phosphorylation in
- migration
- growth
- adhesion
- clustering in
- apoptosis
- formation
- shape change
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cell periphery
- perinuclear region
- focal complexes
- podosomes
- actin cytoskeleton
- Nucleus
- Plasma Membrane
- centrosome
- actin bundles
- cytosol
- endoplasmic reticulum membrane
- membrane ruffles
- spindle pole
- synapse
- mitotic spindle
- filopodial tip
- perikaryon
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Akap12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway
- regulation of protein kinase C signaling cascade
- signal transduction
- positive regulation of oligodendrocyte apoptotic process
- negative regulation of vascular permeability
- positive regulation of protein kinase A signaling cascade
- positive regulation of nitric-oxide synthase biosynthetic process
- regulation of protein kinase A signaling cascade
- positive regulation of ERK1 and ERK2 cascade
- cellular response to interleukin-1
- regulation of synaptic transmission
- response to lipopolysaccharide
- positive regulation of tumor necrosis factor production
- cellular response to tumor necrosis factor
- response to electrical stimulus
- hepatic stellate cell activation
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- focal adhesion
- cytoplasm
- cell cortex
- cytosol
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- protein binding
- adenylate cyclase binding
- protein kinase A binding