Astn2 Gene Summary [Rat]
Predicted to enable calcium ion binding activity and inositol 1,3,4,5 tetrakisphosphate binding activity. Predicted to be involved in neuron cell-cell adhesion and neuron migration. Predicted to act upstream of or within establishment of body hair planar orientation and negative regulation of protein localization to cell surface. Predicted to be located in cell pole. Predicted to be active in endosome and membrane. Orthologous to human ASTN2 (astrotactin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Astn2 |
| Official Name | astrotactin 2 [Source:RGD Symbol;Acc:2320342] |
| Ensembl ID | ENSRNOG00000060105 |
| Bio databases IDs | |
| Aliases | astrotactin 2 |
| Synonyms | 1d8, ASTNL, astrotactin 2, bA67K19.1, bM452J22.1, LOC100291924 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Astn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- ASTN1/2 EGF-like and Fn(III) domains
- MAC/Perforin domain
- FN3
- membrane-attack complex / perforin
- Astrotactin-2 C-terminal beta-hairpin domain
- calcium ion binding
- protein binding
- Astrotactin 1/2 N-terminal
- Coagulation Factor Xa inhibitory site
- EGF repeat
- Annexin-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- coronary artery disease
- right colon cancer
- insomnia
- endometriosis
- non-insulin-dependent diabetes mellitus
- idiopathic scoliosis
- pain
- drug-induced liver disease
- major depression
- migraines
regulates
- ASTN1
- Shiga toxin 2
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- clathrin-coated structures
- cell pole
- cellular membrane
- endosomes
- dendritic spines
- neurites
- early endosomes
- late endosomes
- endocytotic vesicle
- perikaryon
- autophagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Astn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- neuron migration
- negative regulation of protein localization at cell surface
- protein transport
- neuron cell-cell adhesion
- establishment of body hair planar orientation
Cellular Component
Where in the cell the gene product is active
- cell pole
- early endosome
- endosome
- cell cortex
- membrane
- late endosome
- clathrin-coated vesicle
- perikaryon
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- inositol 1,3,4,5 tetrakisphosphate binding