Setd7 Gene Summary [Rat]
Enables chromatin binding activity. Involved in positive regulation of DNA-templated transcription and response to ethanol. Predicted to be located in nucleolus. Predicted to be active in chromosome and nucleus. Used to study extrahepatic cholestasis. Biomarker of fetal alcohol spectrum disorder. Orthologous to human SETD7 (SET domain containing 7, histone lysine methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Setd7 |
| Official Name | SET domain containing 7, histone lysine methyltransferase [Source:RGD Symbol;Acc:1586346] |
| Ensembl ID | ENSRNOG00000013045 |
| Bio databases IDs | |
| Aliases | SET domain containing 7, histone lysine methyltransferase |
| Synonyms | 1600028F23Rik, H3K4MT, KMT7, LOC679429, mKIAA1717, SET7, SET7/9, SET9, SET domain containing 7, histone lysine methyltransferase, SET domain containing (lysine methyltransferase) 7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Setd7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-lysine N-methyltransferase
- histone methyltransferase
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- SET domain
- chromatin binding
- central domain
- enzyme
- p53 binding
- protein binding
Pathways
Biological processes and signaling networks where the Setd7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- castration refractory prostate cancer
- organismal death
- androgenic alopecia
- insulin resistance
- Alzheimer disease
- schizophrenia
- drusen
- impaired glucose tolerance
- bladder cancer
role in cell
- apoptosis
- expression in
- growth
- migration
- proliferation
- cell cycle progression
- binding in
- ubiquitination in
- degradation in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Setd7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterochromatin organization
- response to ethanol
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- peptidyl-lysine monomethylation
- chromatin organization
- response to DNA damage stimulus
- peptidyl-lysine dimethylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- protein binding
- histone methyltransferase activity
- chromatin binding
- protein-lysine N-methyltransferase activity