Foxred1 Gene Summary [Rat]
Predicted to be involved in mitochondrial respiratory chain complex I assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 19. Orthologous to human FOXRED1 (FAD dependent oxidoreductase domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Foxred1 |
| Official Name | FAD-dependent oxidoreductase domain containing 1 [Source:RGD Symbol;Acc:1311785] |
| Ensembl ID | ENSRNOG00000060379 |
| Bio databases IDs | |
| Aliases | FAD-dependent oxidoreductase domain containing 1 |
| Synonyms | FAD-dependent oxidoreductase domain containing 1, FP634, H17, MC1DN19, RGD1311785, TEG-23, TEX23 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Foxred1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD dependent oxidoreductase
- sarcosine oxidase, monomeric form
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- nuclear type 19 mitochondrial complex I deficiency
- mitochondrial encephalopathy
- hereditary disorder
- mitochondrial disorder
- Mitochondrial complex I deficiency
- Leigh syndrome
- nuclear type 1 mitochondrial complex I deficiency
- epilepsy and severe psychomotor retardation
regulates
- Mitochondrial ETC 1
- succinate dehydrogenase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Foxred1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex I assembly
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- cytoplasm
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- oxidoreductase activity