Sart1 Gene Summary [Rat]
Predicted to be involved in mRNA cis splicing, via spliceosome; maturation of 5S rRNA; and positive regulation of cytotoxic T cell differentiation. Predicted to be located in Cajal body; Golgi apparatus; and nuclear speck. Predicted to be part of U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; and catalytic step 2 spliceosome. Orthologous to human SART1 (spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sart1 |
| Official Name | spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP [Source:RGD Symbol;Acc:61930] |
| Ensembl ID | ENSRNOG00000020475 |
| Bio databases IDs | |
| Aliases | spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP |
| Synonyms | Ara1, HAF, HOMS1, SART1259, SNRNP110, Snu66, SPF107, spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP, squamous cell carcinoma antigen recognized by T cells 1, SSCA1, U5-110K |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sart1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- HIND motif
- SART-1 family
Pathways
Biological processes and signaling networks where the Sart1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- survival
role in cell
- replication in
- proliferation
- growth
- expression in
- degradation in
- differentiation
- formation
- splicing by
- Clathrin mediated endocytosis by
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- catalytic step 2 spliceosome
- Cytoplasm
- Golgi Apparatus
- cytosol
- spliceosomes
- nucleoplasm
- nuclear speckles
- Cajal bodies
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sart1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nuclear mRNA cis splicing, via spliceosome
- maturation of 5S rRNA
- positive regulation of cytotoxic T cell differentiation
- nuclear mRNA splicing, via spliceosome
- spliceosomal snRNP assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- cytoplasm
- nuclear speck
- U4/U6 x U5 tri-snRNP complex
- Cajal body
- cytosol
- Golgi apparatus
- U2-type precatalytic spliceosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding