FOXRED1 Gene Summary [Human]
This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Details
| Type | Processed Transcript |
| Official Symbol | FOXRED1 |
| Official Name | FAD dependent oxidoreductase domain containing 1 [Source:HGNC Symbol;Acc:HGNC:26927] |
| Ensembl ID | ENSG00000110074 |
| Bio databases IDs | |
| Aliases | FAD dependent oxidoreductase domain containing 1 |
| Synonyms | FAD-dependent oxidoreductase domain containing 1, FP634, H17, MC1DN19, RGD1311785, TEG-23, TEX23 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FOXRED1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD dependent oxidoreductase
- sarcosine oxidase, monomeric form
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- nuclear type 19 mitochondrial complex I deficiency
- mitochondrial encephalopathy
- hereditary disorder
- mitochondrial disorder
- Mitochondrial complex I deficiency
- Leigh syndrome
- nuclear type 1 mitochondrial complex I deficiency
- epilepsy and severe psychomotor retardation
regulates
- Mitochondrial ETC 1
- succinate dehydrogenase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FOXRED1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex I assembly
Cellular Component
Where in the cell the gene product is active
- respiratory chain complex I
- cytoplasm
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- oxidoreductase activity