Celf2 Gene Summary [Rat]
Enables mRNA 3'-UTR binding activity. Involved in post-transcriptional gene silencing. Predicted to be located in Flemming body and nucleoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 97. Orthologous to human CELF2 (CUGBP Elav-like family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Celf2 |
| Official Name | CUGBP, Elav-like family member 2 [Source:RGD Symbol;Acc:68347] |
| Ensembl ID | ENSRNOG00000023661 |
| Bio databases IDs | |
| Aliases | CUGBP, Elav-like family member 2 |
| Synonyms | B230218O03, B230345P09RIK, BRUNOL3, CUG-BP2, CUGBP Elav-like family member 2, CUGBP, Elav-like family member 2, D230046B21Rik, DEE97, ETR-3, LOC105376406, LOC105376407, mETR-3, NAPOR, NAPOR-1, Napor-2, Napor-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Celf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- RNA recognition motif
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- side effect
- juvenile dermatomyositis
- acute myeloid leukemia
- open-angle glaucoma
- Alzheimer disease
- idiopathic scoliosis
- prostate cancer
- developmental and epileptic encephalopathy type 97
- Huntington disease
role in cell
- phosphorylation in
- apoptosis
- expression in
- proliferation
- invasion by
- G2/M phase
- outgrowth
- quantity
- sphere formation by
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- Flemming body
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Celf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of alternative nuclear mRNA splicing, via spliceosome
- regulation of heart contraction
- mRNA splice site selection
- RNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pre-mRNA binding
- RNA binding
- mRNA 3'-UTR binding