Ccm2 Gene Summary [Rat]
Predicted to be involved in heart development and vasculogenesis. Predicted to act upstream of or within several processes, including circulatory system development; endothelium development; and in utero embryonic development. Predicted to be located in mitochondrion. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 2. Orthologous to human CCM2 (CCM2 scaffold protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccm2 |
| Official Name | CCM2 scaffold protein [Source:RGD Symbol;Acc:1308067] |
| Ensembl ID | ENSRNOG00000060825 |
| Bio databases IDs | |
| Aliases | CCM2 scaffold protein |
| Synonyms | C7orf22, CCM2 scaffold protein, cerebral cavernous malformation 2, LOC685923, MGC4607, OSM, PP10187 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccm2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- harmonin_N_like
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- edema
- cerebral cavernous malformations 2
- cerebral cavernous malformation
- chronic periodontal disease
- myocardial infarction
- coronary artery disease
- failure of heart looping
- stenosis
- familial cerebral cavernous malformation
role in cell
- expression in
- binding in
- phosphorylation in
- formation
- formation in
- degradation in
- destabilization in
- morphology
- organization
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ccm2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- inner ear development
- endothelial tube morphogenesis
- venous blood vessel morphogenesis
- regulation of angiogenesis
- vasculogenesis
- cell-cell junction organization
- pericardium development
- endothelium development
- heart development
- integrin-mediated signaling pathway
- endothelial cell development
- blood vessel endothelial cell differentiation
- in utero embryonic development
- stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding