Aldh1a1 Gene Summary [Rat]
Enables benzaldehyde dehydrogenase (NAD+) activity; identical protein binding activity; and retinal dehydrogenase activity. Involved in several processes, including estrous cycle; maintenance of lens transparency; and retinoic acid metabolic process. Predicted to be located in axon; cytosol; and synapse. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aldh1a1 |
| Official Name | aldehyde dehydrogenase 1 family, member A1 [Source:RGD Symbol;Acc:2087] |
| Ensembl ID | ENSRNOG00000017619 |
| Bio databases IDs | |
| Aliases | aldehyde dehydrogenase 1 family, member A1 |
| Synonyms | Ahd-2, ALDC, aldehyde dehydrogenase 1 family member A1, aldehyde dehydrogenase 1 family, member A1, ALDEHYDE DEHYDROGENASE A1, ALDH1, ALDH11, ALDH1A4, Aldh2, ALDH-E1, HEL12, HEL-9, HEL-S-53e, LOC103695056, PUMB1, RALDH1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Aldh1a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Aldehyde dehydrogenase family
- aminobutyraldehyde dehydrogenase
- retinal dehydrogenase
- aldehyde dehydrogenase
- benzaldehyde dehydrogenase (NAD)
- GTPase activator
- enzyme
- protein binding
- identical protein binding
- androgen binding
- delta-1-pyrroline-5-carboxylate dehydrogenase (PutA C-terminal domain)
- NAD(P)+-dependent aldehyde dehydrogenase superfamily
- 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase
- NAD or NADH binding
- betaine-aldehyde dehydrogenase
- delta-1-pyrroline-5-carboxylate dehydrogenase, group 1
- aldehyde dehydrogenase (NAD)
- delta-1-pyrroline-5-carboxylate dehydrogenase, group 2, putative
- 2-hydroxymuconic semialdehyde dehydrogenase
- methylmalonic acid semialdehyde dehydrogenase
Pathways
Biological processes and signaling networks where the Aldh1a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- diabetes mellitus
- lung cancer
- inflammatory breast cancer
- uterine leiomyoma
- leiomyomatosis
- hemorrhagic cystitis
- non-insulin-dependent diabetes mellitus
role in cell
- apoptosis
- phosphorylation in
- expression in
- migration
- cell viability
- growth
- colony formation
- pH
- colony formation by
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- synapse
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Aldh1a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular aldehyde metabolic process
- retinoid metabolic process
- fructosamine catabolic process
- retinol metabolic process
- gamma-aminobutyric acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
- synapse
- axon
Molecular Function
What the gene product does at the molecular level
- aldehyde dehydrogenase (NAD) activity
- glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
- protein binding
- NAD binding
- GTPase activator activity
- retinal dehydrogenase activity
- aminobutyraldehyde dehydrogenase activity
- androgen binding
- benzaldehyde dehydrogenase (NAD+) activity