Clca1 Gene Summary [Rat]
Predicted to enable intracellularly calcium-gated chloride channel activity. Involved in cellular response to hypoxia. Located in zymogen granule membrane. Human ortholog(s) of this gene implicated in asthma and chronic obstructive pulmonary disease. Orthologous to human CLCA1 (chloride channel accessory 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Clca1 |
| Official Name | chloride channel accessory 1 [Source:RGD Symbol;Acc:1306258] |
| Ensembl ID | ENSRNOG00000060831 |
| Bio databases IDs | |
| Aliases | chloride channel accessory 1 |
| Synonyms | CACC, CACC1, chloride channel accessory 1, Clca2, Clca3, CLCRG1, GOB5, hCaCC-1, hCLCA1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Clca1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcium-activated chloride channel N terminal
- calcium-activated chloride channel protein 1
- von Willebrand factor (vWF) type A domain
- vWFA
- chloride channel
- VWFA-related Acidobacterial domain
- von Willebrand factor type A domain
- ion channel
- metalloendopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- airway hyperresponsiveness
- organismal death
- colon adenocarcinoma
- colon epithelial cancer
regulates
- mucin
- MUC2
- chloride
- ion
- ANO1
- MUC5AC
- chemokine
role in cell
- expression in
- activation
- colony formation
- number
- morphology
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- zymogen granules
- secretory granules
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Clca1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
- proteolysis
- calcium ion transport
- cellular response to hypoxia
Cellular Component
Where in the cell the gene product is active
- microvillus
- extracellular region
- plasma membrane
- zymogen granule membrane
Molecular Function
What the gene product does at the molecular level
- intracellular calcium activated chloride channel activity
- metal ion binding
- chloride channel activity
- metalloendopeptidase activity