Ano1 Gene Summary [Rat]
Enables intracellularly calcium-gated chloride channel activity; iodide transmembrane transporter activity; and signaling receptor binding activity. Involved in cellular response to peptide; chloride transmembrane transport; and iodide transport. Predicted to be located in apical plasma membrane; external side of plasma membrane; and nucleoplasm. Predicted to be active in glutamatergic synapse and presynaptic membrane. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ano1 |
| Official Name | anoctamin 1 [Source:RGD Symbol;Acc:1310786] |
| Ensembl ID | ENSRNOG00000020865 |
| Bio databases IDs | |
| Aliases | anoctamin 1 |
| Synonyms | anoctamin 1, anoctamin 1, calcium activated chloride channel, DOG-1, FLJ10261, INDMS, LOC107984355, MYMY7, ORAOV2, TAOS2, TMEM16A |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ano1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium activated cation channel
- Calcium-activated chloride channel
- dimerization domain of Ca+-activated chloride-channel, anoctamin
- chloride channel
- intracellular calcium activated chloride channel
- protein homodimerization
- protein binding
- receptor binding
- identical protein binding
- voltage-gated chloride channel
- ion channel
- iodide transporter
Pathways
Biological processes and signaling networks where the Ano1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- osteoporosis
- gastrointestinal stromal tumor
- gastrointestinal stromal neoplasia
- pancreatic cancer
- organismal death
- diarrhea
- endometrioma
- colorectal cancer
- autosomal dominant polycystic kidney disease
role in cell
- proliferation
- expression in
- accumulation in
- colony formation
- transmembrane potential
- phosphorylation in
- response by
- invasion by
- invasiveness
- self-renewal
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cilia
- plasma membrane extracellular face
- apical membrane
- presynaptic membrane
- nucleoplasm
- dendritic knobs
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ano1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to heat
- mucus secretion
- ion transmembrane transport
- protein localization in membrane
- iodide transport
- phospholipase C-activating G-protein coupled receptor signaling pathway
- positive regulation of insulin secretion involved in cellular response to glucose stimulus
- detection of temperature stimulus involved in sensory perception of pain
- chloride transport
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- extracellular vesicular exosome
- cell projection
- apical plasma membrane
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- calcium activated cation channel activity
- identical protein binding
- protein homodimerization activity
- intracellular calcium activated chloride channel activity
- protein binding
- iodide transmembrane transporter activity
- metal ion binding
- chloride channel activity
- receptor binding
- voltage-gated chloride channel activity