Crym Gene Summary [Rat]
Predicted to enable several functions, including protein homodimerization activity; thiomorpholine-carboxylate dehydrogenase activity; and thyroid hormone binding activity. Involved in mitochondrial transport; response to hormone; and response to vitamin D. Predicted to be located in cytosol; mitochondrion; and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 40. Orthologous to human CRYM (crystallin mu). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crym |
| Official Name | crystallin, mu [Source:RGD Symbol;Acc:620943] |
| Ensembl ID | ENSRNOG00000061215 |
| Bio databases IDs | |
| Aliases | crystallin, mu |
| Synonyms | Cdk108, CRYSTALLIN MU, crystallin, mu, CTBP, DFNA40, Mu crystallin homolog, THBP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crym often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- hormone binding
- NADP binding
- transcription co-repressor
- NAD binding domain of 6-phosphogluconate dehydrogenase
- protein homodimerization
- enzyme
- protein binding
- alanine dehydrogenase, Archaeoglobus fulgidus type
- thiomorpholine-carboxylate dehydrogenase
- Ornithine cyclodeaminase/mu-crystallin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Huntington disease
- epileptic seizure
- pelvic organ prolapse
- autosomal dominant deafness type 40
- cutaneous telangiectasia
- early missed abortion
- familial nonsyndromic hearing impairment
- proximal tubular toxicity
regulates
- L-triiodothyronine
- DNA promoter
- DNA endogenous promoter
- L-lysine
- RNA polymerase II
- thyroid hormone
- GH1
- LDH (complex)
- levothyroxine
role in cell
- expression in
- transport in
- cross-sectional area
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- Nucleus
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crym gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- negative regulation of transcription from RNA polymerase II promoter
- lysine catabolic process
- thyroid hormone metabolic process
- thyroid hormone transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- NADP binding
- protein binding
- protein homodimerization activity
- transcription corepressor activity
- thyroid hormone binding
- thiomorpholine-carboxylate dehydrogenase activity