Tubb5 Gene Summary [Rat]
Enables GTPase activating protein binding activity and protein domain specific binding activity. Predicted to be involved in microtubule cytoskeleton organization; mitotic cell cycle; and regulation of synapse organization. Predicted to act upstream of or within odontoblast differentiation and spindle assembly. Located in membrane raft. Part of protein-containing complex. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 6 and congenital symmetric circumferential skin creases 1. Orthologous to human TUBB (tubulin beta class I). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tubb5 |
| Official Name | tubulin, beta 5 class I [Source:RGD Symbol;Acc:628596] |
| Ensembl ID | ENSRNOG00000061216 |
| Bio databases IDs | |
| Aliases | tubulin, beta 5 class I |
| Synonyms | B130022C14RIK, Beta tubulin, Beta tubulin 1, CDCBM6, CSCSC1, M40, M(beta)5, M(β)5, OK/SW-cl.56, TBB5, TUBB1, TUBB5, TUBULIN beta 5, tubulin, beta 5 class I, tubulin beta class I, tubulin, beta class I, TUBULIN β 5, tubulin, β 5 class I, tubulin β class I, tubulin, β class I, β tubulin, β tubulin 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tubb5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tubulin protein family of FtsZ and CetZ-like
- ubiquitin protein ligase binding
- Tubulin C-terminal domain
- MHC class I protein binding
- binding protein
- structural constituent of cytoskeleton
- Tubulin/FtsZ family, GTPase domain
- protein domain specific binding
- protein binding
- Tubulin/FtsZ family, C-terminal domain
- structural molecule
Pathways
Biological processes and signaling networks where the Tubb5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- invasive breast cancer
- metastatic invasive breast cancer
- Alzheimer disease
- infection
- schizophrenia
- asthma
- coronary disease
- cardiovascular disorder
- heart failure
- disorder of coronary artery
role in cell
- differentiation
- cell death
- growth
- survival
- assembly
- replication in
- fragmentation
- organization
- polymerization
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane vesicles
- microtubule cytoskeleton
- cytoplasmic ribonucleoprotein granule
- azurophil granule lumen
- cytoskeleton
- Extracellular Space
- cellular membrane
- Nucleus
- centrosome
- microtubules
- midbody
- cytoplasmic bridges
- cytosol
- primary cilia
- inner nuclear membrane
- perinuclear space
- synaptosomes
- membrane rafts
- cleavage furrow
- mitotic spindle
- perikaryon
- phagosomes
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tubb5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- spindle assembly
- cytoskeleton-dependent intracellular transport
- regulation of synapse organization
- odontoblast differentiation
- microtubule cytoskeleton organization
- natural killer cell mediated cytotoxicity
- mitotic cell cycle
- microtubule-based process
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- extracellular region
- nuclear envelope lumen
- microtubule
- nucleus
- intercellular bridge
- extracellular vesicular exosome
- cytoskeleton
- mitotic spindle
- cytoplasm
- membrane raft
- cell body
- cytosol
- macromolecular complex
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein domain specific binding
- protein binding
- ubiquitin protein ligase binding
- metal ion binding
- GTPase activity
- structural molecule activity
- MHC class I protein binding
- structural constituent of cytoskeleton
- GTPase activating protein binding