Metap1d Gene Summary [Rat]

Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in mitochondrion. Orthologous to human METAP1D (methionyl aminopeptidase type 1D, mitochondrial). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Metap1d
Official Name
methionyl aminopeptidase type 1D (mitochondrial) [Source:RGD Symbol;Acc:1307413]
Ensembl ID
ENSRNOG00000061587
Bio databases IDs NCBI: 311748 Ensembl: ENSRNOG00000061587
Aliases methionyl aminopeptidase type 1D (mitochondrial)
Synonyms 2310066F24Rik, 3110033D18Rik, MAP 1D, Metap1l, Metapl1, methionyl aminopeptidase type 1D (mitochondrial), methionyl aminopeptidase type 1D, mitochondrial
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Metap1d often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Metallopeptidase family M24
  • metalloexopeptidase
  • methionine aminopeptidase, type I
  • methionine aminopeptidase, type II
  • peptidase
  • aminopeptidase
  • protein binding
  • APP_MetAP
  • methionyl aminopeptidase

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • insomnia
  • schizophrenia
  • acute myeloid leukemia
  • myopia
  • metabolic syndrome X
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • Mitochondria

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Metap1d gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • proteolysis
  • N-terminal protein amino acid modification
  • peptidyl-methionine modification

Cellular Component

Where in the cell the gene product is active
  • mitochondrion

Molecular Function

What the gene product does at the molecular level
  • methionyl aminopeptidase activity
  • metal ion binding
  • metalloexopeptidase activity
  • metalloaminopeptidase activity
  • aminopeptidase activity