METAP1D Gene Summary [Human]
The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 3.4.11.18) (Serero et al., 2003 [PubMed 14532271]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | METAP1D |
| Official Name | methionyl aminopeptidase type 1D, mitochondrial [Source:HGNC Symbol;Acc:HGNC:32583] |
| Ensembl ID | ENSG00000172878 |
| Bio databases IDs | |
| Aliases | methionyl aminopeptidase type 1D, mitochondrial, methionine aminopeptidase 1D |
| Synonyms | 2310066F24Rik, 3110033D18Rik, MAP 1D, Metap1l, Metapl1, methionyl aminopeptidase type 1D (mitochondrial), methionyl aminopeptidase type 1D, mitochondrial |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human METAP1D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Metallopeptidase family M24
- metalloexopeptidase
- methionine aminopeptidase, type I
- methionine aminopeptidase, type II
- peptidase
- aminopeptidase
- protein binding
- APP_MetAP
- methionyl aminopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human METAP1D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- N-terminal protein amino acid modification
- peptidyl-methionine modification
Cellular Component
Where in the cell the gene product is active
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- methionyl aminopeptidase activity
- metal ion binding
- metalloexopeptidase activity
- metalloaminopeptidase activity
- aminopeptidase activity