Cpeb1 Gene Summary [Rat]
Enables mRNA 3'-UTR binding activity. Involved in several processes, including cellular response to lipopolysaccharide; positive regulation of nitric oxide biosynthetic process; and regulation of translation. Located in several cellular components, including centrosome; growth cone; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Used to study glioblastoma. Biomarker of portal hypertension and primary biliary cholangitis. Orthologous to human CPEB1 (cytoplasmic polyadenylation element binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cpeb1 |
| Official Name | cytoplasmic polyadenylation element binding protein 1 [Source:RGD Symbol;Acc:1310421] |
| Ensembl ID | ENSRNOG00000019161 |
| Bio databases IDs | |
| Aliases | cytoplasmic polyadenylation element binding protein 1 |
| Synonyms | CPEB, CPE-BP1, cytoplasmic polyadenylation element binding protein 1, h-CPEB, hCPEB-1, LOC107987415, mCPEB, mCpeb-1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cpeb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonucleoprotein binding domain
- RNA recognition motif (RRM) superfamily
- Cytoplasmic polyadenylation element-binding protein ZZ domain
- RNA recognition motif
- mRNA binding
- protein binding
- aurora box
- translation regulator
- RNA binding
- Leu-Asp-Ser-Arg motif
- PEST domain
- B-box-type zinc finger superfamily
- mRNA 3' UTR binding
- nucleic acid binding translation repressor
- Cytoplasmic polyadenylation element-binding protein 1 N-terminus
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- metastatic breast cancer
- organismal death
- lung metastasis
- oligozoospermia
- daytime sleepiness
- pervasive developmental disorder
role in cell
- apoptosis
- phosphorylation in
- expression in
- proliferation
- formation
- synthesis in
- motility
- migration
- invasion by
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- perinuclear region
- postsynaptic region
- cellular membrane
- Nucleus
- centrosome
- cytosol
- nucleoplasm
- growth cone
- synaptosomes
- synapse
- meiotic spindles
- perikaryon
- dendrites
- postsynaptic density
- excitatory synapses
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cpeb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- cellular response to amino acid stimulus
- regulation of mRNA 3'-end processing
- mRNA processing
- cellular response to hypoxia
- negative regulation of cytoplasmic translation
- translation
Cellular Component
Where in the cell the gene product is active
- dendrite
- postsynaptic density
- nucleus
- cytoplasm
- membrane
- cytosol
- cytoplasmic mRNA processing body
- synapse
- neuron projection
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- mRNA 3'-UTR AU-rich region binding
- metal ion binding
- ribosome binding
- translation repressor activity, nucleic acid binding
- translation factor activity, nucleic acid binding
- mRNA 3'-UTR binding