Asxl1 Gene Summary [Rat]
Predicted to enable several functions, including nuclear retinoic acid receptor binding activity; peroxisome proliferator activated receptor binding activity; and transcription coactivator activity. Involved in negative regulation of lipid storage. Predicted to be located in nucleus. Predicted to be part of PR-DUB complex. Human ortholog(s) of this gene implicated in SM-AHNMD; acute myeloid leukemia; chronic myelomonocytic leukemia; myelodysplastic syndrome; and myelofibrosis. Orthologous to human ASXL1 (ASXL transcriptional regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Asxl1 |
| Official Name | ASXL transcriptional regulator 1 [Source:RGD Symbol;Acc:1561878] |
| Ensembl ID | ENSRNOG00000061603 |
| Bio databases IDs | |
| Aliases | ASXL transcriptional regulator 1 |
| Synonyms | ASXL transcriptional regulator 1, BOPS, LOC228790, MDS, RGD1561878 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Asxl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- peroxisome proliferator activated receptor binding
- HB1, ASXL, restriction endonuclease HTH domain
- retinoic acid receptor binding
- DEUBAD_NFRKB
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- myelodysplastic syndrome
- chronic myelomonocytic leukemia
- myelodysplastic-myeloproliferative disease
- neoplasia
- secondary acute myeloid leukemia
- chronic neutrophilic leukemia
- chronic myeloid leukemia
- primary myelofibrosis
- myeloid/lymphoid neoplasm with eosinophilia
role in cell
- expression in
- differentiation
- development
- abnormal morphology
- morphogenesis
- number
- adipogenesis in
- deubiquitination in
- hematopoiesis
- abnormality
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Asxl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung saccule development
- regulation of kidney size
- cell morphogenesis
- hemopoiesis
- negative regulation of fat cell differentiation
- chromatin organization
- positive regulation of transcription from RNA polymerase II promoter
- bone marrow development
- organ morphogenesis
- thymus development
- positive regulation of retinoic acid receptor signaling pathway
- heart morphogenesis
- response to retinoic acid
- glomerular visceral epithelial cell development
- homeostasis of number of cells
- negative regulation of peroxisome proliferator activated receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- PR-DUB complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription coactivator activity
- metal ion binding
- chromatin binding
- retinoic acid receptor binding
- peroxisome proliferator activated receptor binding