Mcm7 Gene Summary [Rat]
Predicted to enable ATP binding activity; ATP-dependent activity, acting on DNA; and DNA binding activity. Predicted to contribute to DNA helicase activity and single-stranded DNA binding activity. Involved in cellular response to epidermal growth factor stimulus and response to xenobiotic stimulus. Predicted to be located in nucleus. Predicted to be part of CMG complex and MCM complex. Used to study hepatocellular carcinoma. Biomarker of hepatocellular carcinoma and hyperthyroidism. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mcm7 |
| Official Name | minichromosome maintenance complex component 7 [Source:RGD Symbol;Acc:1303018] |
| Ensembl ID | ENSRNOG00000001349 |
| Bio databases IDs | |
| Aliases | minichromosome maintenance complex component 7 |
| Synonyms | AI747533, CDC47, D16Mgi24, mCDC47, MCM2, Mcmd7, minichromosome maintenance complex component 7, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mcm7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- walker type B motif
- walker type A motif
- ATP binding
- MCM P-loop domain
- enzyme
- protein binding
- DNA dependent ATPase
- Rxl motif
- MCM AAA-lid domain
- DNA binding
- DNA helicase
- MCM helicase family
- minichromosome maintenance proteins
- AAA domain (dynein-related subfamily)
- MCM OB domain
- single-stranded DNA binding
- ATPase domain
- MCM N-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Mcm7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cervical cancer
- prostate cancer
- organismal death
- small cell lung cancer
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- endometriosis
- Meier-Gorlin syndrome
role in cell
- activation in
- proliferation
- migration
- growth
- cell death
- cell viability
- S phase
- association
- response by
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- detergent-insoluble fractions
- cytosol
- nuclear foci
- nucleoplasm
- chromatin
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mcm7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- DNA-dependent DNA replication initiation
- double-strand break repair via break-induced replication
- DNA strand elongation involved in DNA replication
- regulation of DNA-dependent DNA replication initiation
- DNA replication
- cellular response to xenobiotic stimulus
- response to DNA damage stimulus
- regulation of phosphorylation
- DNA unwinding involved in replication
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nucleus
- CMG complex
- membrane
- cytosol
- nucleolus
- MCM complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- DNA helicase activity
- protein binding
- single-stranded DNA-dependent ATP-dependent DNA helicase activity
- single-stranded DNA binding