Gsc

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in middle ear morphogenesis and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including chordate embryonic development; negative regulation of Wnt signaling pathway; and signal transduction involved in regulation of gene expression. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; forebrain; genitourinary system; limb; and sensory organ. Orthologous to human GSC (goosecoid homeobox). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gsc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Gsc gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Gsc gene, providing context for its role in the cell.