Serpinb1a Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including inflammatory response; negative regulation of interleukin-1 beta production; and type B pancreatic cell proliferation. Acts upstream of or within regulation of protein catabolic process. Located in extracellular region. Is expressed in bladder wall; brain; embryo mesenchyme; gut; and liver lobe. Orthologous to human SERPINB1 (serpin family B member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Serpinb1a |
| Official Name | serine (or cysteine) peptidase inhibitor, clade B, member 1a [Source:MGI Symbol;Acc:MGI:1913472] |
| Ensembl ID | ENSMUSG00000044734 |
| Bio databases IDs | |
| Aliases | serine (or cysteine) peptidase inhibitor, clade B, member 1a |
| Synonyms | 1190005M04Rik, EI, EIA, ELANH2, LEI, MNEI, M/NEI, Monocyte/neutrophil elastase inhibitor, PI2, serine (or cysteine) peptidase inhibitor, clade B, member 1a, Serpinb1, serpin family B member 1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Serpinb1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- protease inhibitor
- serine protease inhibitor activity
- protein binding
- Serpin (serine protease inhibitor)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neutropenia
- infection by bacteria
- experimental autoimmune encephalomyelitis
- sepsis
role in cell
- apoptosis
- chemotaxis
- frequency
- number
- function
- homeostasis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cytoplasmic ribonucleoprotein granule