Ctsg Gene Summary [Mouse]
This gene encodes a member of the peptidase S1 (chymotrypsin) family of serine endopeptidases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product appears to play a role in host defense, including inflammation and antigen processing. Homozygous knockout mice for this gene exhibit enhanced susceptibility to bacterial and fungal infection. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Ctsg |
| Official Name | cathepsin G [Source:MGI Symbol;Acc:MGI:88563] |
| Ensembl ID | ENSMUSG00000040314 |
| Bio databases IDs | |
| Aliases | cathepsin G |
| Synonyms | CATG, Cathepsin G, CG, VSP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ctsg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- serine endopeptidase
- trypsin
- Tryp_SPc
- serine-type peptidase
- protease binding
- peptidase
- receptor agonist activity
- Trypsin-like peptidase domain
- protein binding
- heparin binding
- cathepsin G
Pathways
Biological processes and signaling networks where the Ctsg gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- systemic lupus erythematosus
- cancer
- septic shock
- diabetic nephropathy
- pruritus
- neoplasia
- colorectal cancer
- androgenic alopecia
- acute respiratory distress syndrome
role in cell
- activation in
- expression in
- proliferation
- activation
- binding
- cell death
- phosphorylation in
- apoptosis
- production in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- extracellular trap
- azurophil granule lumen
- cell surface
- Extracellular Space
- cellular membrane
- Nucleus
- vacuole
- Plasma Membrane
- lysosome
- Golgi Apparatus
- granules
- cytosol
- azurophil granules
- stress granule
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ctsg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neutrophil activation
- protein metabolic process
- neutrophil mediated killing of gram-positive bacterium
- purinergic nucleotide receptor signaling pathway
- defense response to Gram-negative bacterium
- extracellular matrix disassembly
- protein phosphorylation
- angiotensin maturation
- immune response
- cellular response to lipopolysaccharide
- monocyte chemotaxis
- cytokine-mediated signaling pathway
- proteolysis
- protein processing
- antibacterial humoral response
- negative regulation of T cell activation
- defense response to fungus
- positive regulation of immune response
- platelet activation
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- secretory granule
- extracellular region
- plasma membrane
- lysosome
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- cytosol
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type peptidase activity
- serine-type endopeptidase activity
- receptor agonist activity
- heparin binding
- peptidase activity