Jchain Gene Summary [Mouse]
Enables IgA binding activity and protein-macromolecule adaptor activity. Contributes to immunoglobulin receptor binding activity. Predicted to be involved in several processes, including defense response to symbiont; glomerular filtration; and positive regulation of respiratory burst. Part of dimeric IgA immunoglobulin complex. Is expressed in intestine; serum; and spleen. Orthologous to human JCHAIN (joining chain of multimeric IgA and IgM). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Jchain |
| Official Name | immunoglobulin joining chain [Source:MGI Symbol;Acc:MGI:96493] |
| Ensembl ID | ENSMUSG00000067149 |
| Bio databases IDs | |
| Aliases | immunoglobulin joining chain |
| Synonyms | 9530090F24Rik, IGCJ, IGJ, Ig joining chain, immunoglobulin joining chain, JCH, joining chain of multimeric IgA and IgM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Jchain often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin J chain
- phospholipid binding
- binding protein
- single-stranded DNA binding
- protein binding activity, bridging
- antigen binding
- protein homodimerization
- peptidoglycan binding
- receptor binding
- IgA binding
Pathways
Biological processes and signaling networks where the Jchain gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Allograft Rejection Signaling
- Autoimmune Thyroid Disease Signaling
- B Cell Receptor Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- IL-12 Signaling and Production in Macrophages
- Phagosome Formation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- organismal death
- colorectal cancer
- plasma cell neoplasm
- B cell cancer
- mature B-cell neoplasia
- breast cancer
- endometriosis
- liver cancer
role in cell
- proliferation
- function
- migration
- invasion by
- epithelial-mesenchymal transition
- number
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Jchain gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of respiratory burst
- immune response
- macromolecular complex assembly
- innate immune response
- glomerular filtration
- humoral immune response
- adaptive immune response
- antibacterial humoral response
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- dimeric IgA immunoglobulin complex
- secretory IgA immunoglobulin complex
- blood microparticle
- secretory dimeric IgA immunoglobulin complex
- extracellular region
- monomeric IgA immunoglobulin complex
- pentameric IgM immunoglobulin complex
- hexameric IgM immunoglobulin complex
Molecular Function
What the gene product does at the molecular level
- peptidoglycan binding
- protein homodimerization activity
- antigen binding
- IgA binding
- phosphatidylcholine binding
- protein binding, bridging
- immunoglobulin receptor binding
- single-stranded DNA binding