Sin3a Gene Summary [Rat]
Enables RNA binding activity. Involved in cellular response to dopamine; cellular response to tert-butyl hydroperoxide; and regulation of hormone levels. Located in chromatin and nucleus. Part of protein-containing complex. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sin3a |
| Official Name | SIN3 transcription regulator family member A [Source:RGD Symbol;Acc:1311598] |
| Ensembl ID | ENSRNOG00000032254 |
| Bio databases IDs | |
| Aliases | SIN3 transcription regulator family member A |
| Synonyms | CHR15DELq24, DEL15Q24, mKIAA4126, MSIN3A, SIN3, SIN3 transcription regulator family member A, transcriptional regulator, SIN3A (yeast), WITKOS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sin3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Histone deacetylase (HDAC) interacting
- amphipathic helix
- transcription co-repressor
- transcription factor binding
- chromatin binding
- protein binding
- DNA binding
- RNA binding
- Paired amphipathic helix repeat
- binding protein
- C-terminal domain of Sin3a protein
- Sin3 family co-repressor
Pathways
Biological processes and signaling networks where the Sin3a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Bladder Cancer Signaling
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Glioma Signaling
- Huntington's Disease Signaling
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Nur77 Signaling in T Lymphocytes
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- Huntington disease
- breast cancer
- Witteveen-Kolk syndrome
- hereditary disorder
- renal cancer
- duodenal-type follicular lymphoma
- follicular non-Hodgkin disease
- duodenal cancer
- liver cancer
role in cell
- survival
- proliferation
- cell viability
- length
- apoptosis
- transmembrane potential
- differentiation
- invasion by
- response by
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- Cytoplasm
- nucleoplasm
- kinetochores
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sin3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein localization to nucleus
- DNA replication
- protein localization
- positive regulation of neuron differentiation
- positive regulation of defense response to virus by host
- hemopoietic progenitor cell differentiation
- negative regulation of circadian rhythm
- cerebral cortex neuron differentiation
- type I interferon-mediated signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- regulation of hormone levels
- regulation of axon extension
- negative regulation of transcription, DNA-dependent
- rhythmic process
- activation of innate immune response
- response to methylglyoxal
- cellular response to glucose stimulus
- in utero embryonic development
- heterochromatin assembly
- negative regulation of apoptotic process
- negative regulation of cell migration
- negative regulation of transforming growth factor beta receptor signaling pathway
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcriptional repressor complex
- histone deacetylase complex
- kinetochore
- nucleolus
- chromatin
- nucleoplasm
- Sin3-type complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA binding
- protein binding
- transcription corepressor activity
- chromatin binding