Baz2a Gene Summary [Rat]
Predicted to enable several functions, including DNA binding activity; chromatin-protein adaptor activity; and lysine-acetylated histone binding activity. Predicted to contribute to RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in DNA methylation-dependent constitutive heterochromatin formation and negative regulation of transcription by RNA polymerase I. Predicted to act upstream of or within rDNA heterochromatin formation. Predicted to be located in cytosol; nuclear speck; and nucleolus. Predicted to be part of NoRC complex and chromatin silencing complex. Predicted to be active in rDNA heterochromatin. Orthologous to human BAZ2A (bromodomain adjacent to zinc finger domain 2A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Baz2a |
| Official Name | bromodomain adjacent to zinc finger domain, 2A [Source:RGD Symbol;Acc:1305037] |
| Ensembl ID | ENSRNOG00000053881 |
| Bio databases IDs | |
| Aliases | bromodomain adjacent to zinc finger domain, 2A |
| Synonyms | bromodomain adjacent to zinc finger domain 2A, bromodomain adjacent to zinc finger domain, 2A, C030005G16Rik, mKIAA0314, TIP5, WALp3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Baz2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- PHD zinc finger
- Tip5/arbp/mbd domain
- transcription regulator
- nucleic acid binding
- protein binding activity, bridging
- DDT domain
- protein binding
- Bromodomain
- sequence-specific DNA binding
- DNA binding
- RNA binding
- double-stranded DNA binding
- AT hook domain
- PHD finger superfamily
- MBD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
role in cell
- expression in
- binding in
- formation
- movement
- organization
- remodeling
- remodeling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Baz2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA polymerase I transcriptional preinitiation complex assembly
- chromatin remodeling
- transcription, DNA-dependent
- chromatin silencing at rDNA
- heterochromatin assembly
- regulation of transcription, DNA-dependent
- methylation-dependent chromatin silencing
- negative regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- cytosol
- rDNA heterochromatin
- nucleolus
- chromatin silencing complex
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- RNA binding
- protein binding
- RNA polymerase I CORE element sequence-specific DNA binding
- histone binding
- metal ion binding
- histone acetyl-lysine binding