Baz2a Gene Summary [Mouse]
Enables several functions, including DNA binding activity; chromatin-protein adaptor activity; and lysine-acetylated histone binding activity. Involved in DNA methylation-dependent constitutive heterochromatin formation; negative regulation of transcription by RNA polymerase I; and rDNA heterochromatin formation. Acts upstream of or within chromatin remodeling. Located in nucleolus and rDNA heterochromatin. Part of NoRC complex and chromatin silencing complex. Is expressed in several structures, including central nervous system; early conceptus; eye; genitourinary system; and paraxial mesenchyme. Orthologous to human BAZ2A (bromodomain adjacent to zinc finger domain 2A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Baz2a |
| Official Name | bromodomain adjacent to zinc finger domain, 2A [Source:MGI Symbol;Acc:MGI:2151152] |
| Ensembl ID | ENSMUSG00000040054 |
| Bio databases IDs | |
| Aliases | bromodomain adjacent to zinc finger domain, 2A |
| Synonyms | bromodomain adjacent to zinc finger domain 2A, bromodomain adjacent to zinc finger domain, 2A, C030005G16Rik, mKIAA0314, TIP5, WALp3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Baz2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- PHD zinc finger
- Tip5/arbp/mbd domain
- transcription regulator
- nucleic acid binding
- protein binding activity, bridging
- DDT domain
- protein binding
- Bromodomain
- sequence-specific DNA binding
- DNA binding
- RNA binding
- double-stranded DNA binding
- AT hook domain
- PHD finger superfamily
- MBD
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
role in cell
- expression in
- binding in
- formation
- movement
- organization
- remodeling
- remodeling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Baz2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA polymerase I transcriptional preinitiation complex assembly
- chromatin remodeling
- transcription, DNA-dependent
- chromatin silencing at rDNA
- heterochromatin assembly
- regulation of transcription, DNA-dependent
- methylation-dependent chromatin silencing
- negative regulation of transcription from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- cytosol
- rDNA heterochromatin
- nucleolus
- chromatin silencing complex
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- RNA binding
- protein binding
- RNA polymerase I CORE element sequence-specific DNA binding
- histone binding
- metal ion binding
- histone acetyl-lysine binding