Fabp5 Gene Summary [Rat]
Enables fatty acid binding activity. Predicted to be involved in several processes, including lipid transport across blood-brain barrier; positive regulation of cold-induced thermogenesis; and positive regulation of peroxisome proliferator activated receptor signaling pathway. Predicted to act upstream of or within several processes, including glucose homeostasis; negative regulation of D-glucose transmembrane transport; and phosphatidylcholine biosynthetic process. Predicted to be located in cytoplasm; extracellular space; and postsynaptic density. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic cytosol; and postsynaptic density, intracellular component. Orthologous to human FABP5 (fatty acid binding protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fabp5 |
| Official Name | fatty acid binding protein 5 [Source:RGD Symbol;Acc:70997] |
| Ensembl ID | ENSRNOG00000049075 |
| Bio databases IDs | |
| Aliases | fatty acid binding protein 5 |
| Synonyms | C-FABP, DA11, E-FABP, Fabpe, Fabp epithelial, fatty acid binding protein 5, fatty acid binding protein 5, epidermal, KFABP, Klbp, mal1, PA-FABP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fabp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- long-chain fatty acid transporter
- lipid binding
- binding protein
- lipocalin/cytosolic fatty acid-binding protein family
- fatty acid binding
- protein binding
- retinoid binding
- identical protein binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the Fabp5 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- hepatocellular carcinoma
- liver cancer
- colorectal cancer
- nonalcoholic fatty liver disease
- metastasis
- epithelial cancer
- obesity
- papillomatosis
role in cell
- expression in
- cell viability
- proliferation
- quantity
- invasion by
- migration
- differentiation
- production in
- accumulation in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- azurophil granule lumen
- organelle
- Extracellular Space
- Nucleus
- Plasma Membrane
- secretory granule membrane
- cytosol
- nucleoplasm
- nucleoli
- growth cone
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fabp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of glucose transport
- long-chain fatty acid transport
- fatty acid transport
- positive regulation of peroxisome proliferator activated receptor signaling pathway
- regulation of prostaglandin biosynthetic process
- lipid metabolic process
- glucose homeostasis
- epidermis development
- glucose metabolic process
- phosphatidylcholine biosynthetic process
- regulation of sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- secretory granule membrane
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
- synapse
- extracellular region
- plasma membrane
- azurophil granule lumen
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- retinoic acid binding
- identical protein binding
- fatty acid binding
- protein binding
- lipid binding
- long-chain fatty acid transporter activity