Nup50 Gene Summary [Rat]
Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within neural tube formation. Part of nuclear pore. Orthologous to human NUP50 (nucleoporin 50). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nup50 |
| Official Name | nucleoporin 50 [Source:RGD Symbol;Acc:3191] |
| Ensembl ID | ENSRNOG00000013423 |
| Bio databases IDs | |
| Aliases | nucleoporin 50 |
| Synonyms | 1700030K07Rik, NPAP60, NPAP60L, nucleoporin 50, Rtp60 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nup50 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FXFG repeat
- importin alpha binding domain
- NUP50 (Nucleoporin 50 kDa)
- protein binding
- Pleckstrin homology-like domain
- transporter
- Ran binding domain
Pathways
Biological processes and signaling networks where the Nup50 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amyotrophic lateral sclerosis
- schizophrenia
- acute myeloid leukemia
- uterine leiomyoma
- leiomyomatosis
- infection by HIV-1
role in cell
- nuclear import in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- membrane fraction
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- nuclear rim
- nuclear envelope
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nup50 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nucleocytoplasmic transport
- protein import into nucleus
- mRNA transport
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nuclear membrane
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding