Ncoa2 Gene Summary [Rat]
Enables DNA polymerase binding activity and nuclear receptor binding activity. Involved in several processes, including positive regulation of female receptivity; positive regulation of nuclear receptor-mediated glucocorticoid signaling pathway; and response to estradiol. Located in dendritic spine. Used to study polycystic ovary syndrome. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; lung non-small cell carcinoma; and prostate adenocarcinoma. Orthologous to human NCOA2 (nuclear receptor coactivator 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncoa2 |
| Official Name | nuclear receptor coactivator 2 [Source:RGD Symbol;Acc:620108] |
| Ensembl ID | ENSRNOG00000007975 |
| Bio databases IDs | |
| Aliases | nuclear receptor coactivator 2 |
| Synonyms | bHLHe75, D1Ertd433e, GRIP-1, KAT13C, LOC102549300, nuclear receptor coactivator 2, SRC-2, TIF-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ncoa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- LXXLL motif
- transcription co-activator
- retinoic acid receptor binding
- chromatin binding
- transcription factor binding
- Unstructured region on nuclear receptor coactivator protein
- glutamine-rich domain
- estrogen receptor binding
- nuclear receptor binding domain
- receptor binding domain
- aryl hydrocarbon receptor binding
- Nuclear receptor coactivator
- Steroid receptor coactivator
- helix-loop-helix domain
- Nuclear receptor coactivator, DUF1518
- AD2 domain
- activation domain
- nuclear receptor domain
- AD1 domain
- ligand-dependent nuclear receptor interactor
- Domain of unknown function (DUF4927)
- nucleic acid binding
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- enzyme binding
- protein domain specific binding
- central domain
- protein binding
- receptor binding
- sequence-specific DNA binding
- basic helix loop helix/Per Arnt Sim domain
- thyroid hormone receptor binding
- activation domain AD1
- PAS fold
- auxiliary nuclear receptor binding domain
- p300/cbp binding domain
- transcription repression domain
- binding protein
- PAS domain
- double-stranded DNA binding
- helix loop helix domain
- retinoid X receptor binding
Pathways
Biological processes and signaling networks where the Ncoa2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- ovarian cancer
- non-small cell lung cancer
- colorectal cancer
- weight loss
- obesity
- multiple sclerosis
- systemic lupus erythematosus
- hypoplasia
- drug allergy
role in cell
- activation in
- expression in
- apoptosis
- proliferation
- quantity
- invasion by
- migration
- transactivation in
- production in
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- spliceosomes
- nuclear foci
- nucleoplasm
- nuclear bodies
- dendritic spines
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ncoa2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- regulation of cellular response to insulin stimulus
- response to progesterone stimulus
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- circadian regulation of gene expression
- regulation of glucose metabolic process
- locomotor rhythm
- cellular response to hormone stimulus
- regulation of lipid metabolic process
- peroxisome proliferator activated receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- nuclear body
- cytoplasm
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ligand-dependent nuclear receptor binding
- protein domain specific binding
- protein binding
- transcription coactivator activity
- aryl hydrocarbon receptor binding
- RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- ligand-dependent nuclear receptor transcription coactivator activity
- protein dimerization activity
- chromatin binding