Txnip Gene Summary [Mouse]
Enables enzyme inhibitor activity. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; platelet-derived growth factor receptor signaling pathway; and protein import into nucleus. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Reye syndrome and hepatocellular carcinoma. Orthologous to human TXNIP (thioredoxin interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Txnip |
| Official Name | thioredoxin interacting protein [Source:MGI Symbol;Acc:MGI:1889549] |
| Ensembl ID | ENSMUSG00000038393 |
| Bio databases IDs | |
| Aliases | thioredoxin interacting protein |
| Synonyms | 1200008J08Rik, ARRDC6, EST01027, HHCPA78, HYPLIP1, LOC101060503, TBP-2, THIF, thioredoxin interacting protein, VDUP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Txnip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- arrestin domain
- ubiquitin protein ligase binding
- Arrestin (or S-antigen), C-terminal domain
- enzyme inhibitor activity
- protein binding
- Arrestin (or S-antigen), N-terminal domain
- proline tyrosine motif
Pathways
Biological processes and signaling networks where the Txnip gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
- atopic dermatitis
- psoriasis
- neoplasia
- chronic stable angina
- epithelial cancer
- metastasis
- COVID-19
- diabetes mellitus
- hepatic steatosis
phenotypes
- abnormal retina morphology
- decreased bone mineral content
- decreased bone mineral density
- decreased circulating alkaline phosphatase level
- decreased circulating bilirubin level
- increased circulating calcium level
- increased circulating phosphate level
- increased circulating triglyceride level
- increased total body fat amount
- abnormal NK cell morphology
- abnormal NK cell physiology
- abnormal adipose tissue amount
- abnormal blood homeostasis
- abnormal bone mineral density
- abnormal bone mineralization
- abnormal cellular respiration
- abnormal circulating alkaline phosphatase level
- abnormal circulating calcium level
- abnormal circulating insulin level
- abnormal circulating phosphate level
- abnormal circulating phospholipid level
- abnormal circulating triglyceride level
- abnormal gluconeogenesis
- abnormal glucose homeostasis
- abnormal heart left ventricle morphology
- abnormal ileum morphology
- abnormal lipid homeostasis
- abnormal mesenteric lymph node morphology
- altered response of heart to induced stress
- decreased CD8-positive alpha-beta T cell number
- decreased NK T cell number
- decreased NK cell number
- decreased cellular glucose uptake
- decreased circulating antithrombin level
- decreased circulating glucose level
- decreased circulating sodium level
- decreased physiological sensitivity to xenobiotic
- decreased ventricle muscle contractility
- hematuria
- hepatic steatosis
- hypoglycemia
- improved glucose tolerance
- increased T cell proliferation
- increased bleeding time
- increased blood urea nitrogen level
- increased cardiac cell glucose uptake
- increased circulating VLDL cholesterol level
- increased circulating cholesterol level
- increased circulating free fatty acid level
- increased circulating ketone body level
- increased circulating lactate level
- increased circulating potassium level
- increased fatty acid level
- increased hepatocellular carcinoma incidence
- increased insulin sensitivity
- increased liver weight
- increased lymphocyte cell number
- increased muscle cell glucose uptake
- increased partial thromboplastin time
- increased prothrombin time
- increased regulatory T cell number
- increased sensitivity to induced morbidity/mortality
- kidney failure
- liver degeneration
- macrovesicular hepatic steatosis
- microvesicular hepatic steatosis
- no abnormal phenotype detected
role in cell
- expression in
- apoptosis
- phosphorylation in
- activation in
- cell death
- production in
- proliferation
- generation in
- quantity
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular compartment
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Txnip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to progesterone stimulus
- protein transport
- platelet-derived growth factor receptor signaling pathway
- response to hydrogen peroxide
- response to xenobiotic stimulus
- regulation of cell proliferation
- response to mechanical stimulus
- negative regulation of transcription from RNA polymerase II promoter
- keratinocyte differentiation
- response to oxidative stress
- inflammatory response
- response to glucose stimulus
- negative regulation of cell division
- protein import into nucleus
- response to calcium ion
- positive regulation of apoptotic process
- response to estradiol stimulus
- cellular response to tumor cell
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding
- enzyme inhibitor activity