Mta1 Gene Summary [Mouse]
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coactivator activity. Involved in several processes, including circadian regulation of gene expression; entrainment of circadian clock by photoperiod; and locomotor rhythm. Located in cytoplasm and nucleus. Part of NuRD complex. Is expressed in several structures, including brain; early conceptus; eye; genitourinary system; and mandibular process mesenchyme. Orthologous to human MTA1 (metastasis associated 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mta1 |
| Official Name | metastasis associated 1 [Source:MGI Symbol;Acc:MGI:2150037] |
| Ensembl ID | ENSMUSG00000021144 |
| Bio databases IDs | |
| Aliases | metastasis associated 1 |
| Synonyms | metastasis associated 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mta1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- transcription regulator
- LXXLL motif
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- transcription co-activator
- DNA binding domain
- nucleic acid binding
- transcription co-repressor
- ELM domain
- enzyme binding
- MTA R1 domain
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- Sh3 domain binding motif
- BAH
- BAH domain
- ELM2 domain
- double-stranded DNA binding
- Myb-like DNA-binding domain
- zinc finger binding to DNA consensus sequence [AT]GATA[AG]
- ZnF_GATA
Pathways
Biological processes and signaling networks where the Mta1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- lymphoma
- diffuse large B-cell lymphoma
- cancer
- epithelial neoplasia
- lymphomagenesis
- epithelial cancer
- metastasis
- systemic autoimmune syndrome
- bleomycin-induced pulmonary fibrosis
role in cell
- expression in
- proliferation
- growth
- survival
- activation in
- signaling in
- phosphorylation in
- transformation
- migration
- sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Cytoplasm
- Golgi Apparatus
- Endoplasmic Reticulum
- microtubules
- cytosol
- nucleoplasm
- nuclear envelope
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mta1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- regulation of cell fate specification
- signal transduction
- double-strand break repair
- negative regulation of transcription from RNA polymerase II promoter
- circadian regulation of gene expression
- proteasomal ubiquitin-dependent protein catabolic process
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- locomotor rhythm
- regulation of stem cell differentiation
- entrainment of circadian clock by photoperiod
- response to ionizing radiation
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- NuRD complex
- cytosol
- microtubule
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone deacetylase binding
- transcription coactivator activity
- transcription corepressor activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- chromatin binding