Foxp3 Gene Summary [Mouse]
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene result in the scurfy phenotype (sf). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Foxp3 |
| Official Name | forkhead box P3 [Source:MGI Symbol;Acc:MGI:1891436] |
| Ensembl ID | ENSMUSG00000039521 |
| Bio databases IDs | |
| Aliases | forkhead box P3 |
| Synonyms | AIID, DIETER, Forkhead box P3, FOXP3A, IPEX, JM2, PIDX, RGD1562112, scurfin, sf, XPID |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Foxp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- FH_FOX
- nucleic acid binding
- transcription co-repressor
- transcription factor binding
- histone deacetylase binding
- leucine zipper domain
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- Forkhead domain
- FORKHEAD
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- FOXP coiled-coil domain
- double-stranded DNA binding
- protein homodimerization
- zinc finger domain
- transcription factor activity
- histone acetyltransferase binding
Pathways
Biological processes and signaling networks where the Foxp3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- inflammatory bowel disease
- autoimmune inflammation
- neoplasia
- kidney disease
- anemia
- insulin-dependent diabetes mellitus secretory diarrhea syndrome
- metastasis
- mastocytosis
- autoimmune disease
- immunodeficiency
phenotypes
- abnormal B cell physiology
- abnormal CD4-positive CD25-positive alpha-beta regulatory T cell morphology
- abnormal CD4-positive alpha beta T cell morphology
- abnormal CD4-positive alpha-beta T cell physiology
- abnormal CD8-positive alpha-beta T cell physiology
- abnormal Peyer's patch morphology
- abnormal T cell differentiation
- abnormal T cell subpopulation ratio
- abnormal atrial thrombosis
- abnormal breathing pattern
- abnormal chemokine level
- abnormal cytokine secretion
- abnormal dendritic cell physiology
- abnormal epidermal layer morphology
- abnormal erythrocyte morphology
- abnormal gut-associated lymphoid tissue morphology
- abnormal hepatic cord morphology
- abnormal homeostasis
- abnormal immune system organ morphology
- abnormal immune system physiology
- abnormal inflammatory response
- abnormal intraepithelial T cell morphology
- abnormal liver morphology
- abnormal lymph node B cell domain morphology
- abnormal lymph node T cell domain morphology
- abnormal lymph node medullary cord morphology
- abnormal lymph node morphology
- abnormal lymphocyte morphology
- abnormal lymphocyte physiology
- abnormal macrophage morphology
- abnormal male reproductive system morphology
- abnormal megakaryocyte progenitor cell morphology
- abnormal mesenteric lymph node morphology
- abnormal regulatory T cell morphology
- abnormal regulatory T cell physiology
- abnormal reproductive system development
- abnormal respiratory mucosa goblet cell morphology
- abnormal reticulocyte morphology
- abnormal spleen B cell follicle morphology
- abnormal spleen morphology
- abnormal spleen white pulp morphology
- abnormal tail ring morphology
- abnormal thymus cortex morphology
- abnormal thymus morphology
- absent prostate gland anterior lobe
- absent regulatory T cells
- absent scrotum
- absent seminal vesicle
- absent spleen marginal zone
- alopecia
- anemia
- anisocytosis
- autoimmune response
- azoospermia
- blepharitis
- bradykinesia
- cachexia
- colitis
- conjunctivitis
- cryptorchism
- crypts of Lieberkuhn abscesses
- decreased CD4-positive CD25-positive alpha-beta regulatory T cell number
- decreased T cell number
- decreased body size
- decreased body weight
- decreased double-positive T cell number
- decreased erythrocyte cell number
- decreased hematocrit
- decreased hemoglobin content
- decreased megakaryocyte cell number
- decreased regulatory T cell number
- decreased thymocyte number
- delayed eyelid opening
- dermatitis
- diarrhea
- distended abdomen
- dry skin
- enlarged heart
- enlarged liver
- enlarged liver sinusoidal spaces
- enlarged lymph nodes
- enlarged spleen
- epidermal hyperplasia
- extramedullary hematopoiesis
- gastrointestinal hemorrhage
- hemosiderosis
- hunched posture
- increased CD4-positive alpha beta T cell number
- increased CD8-positive alpha-beta T cell number
- increased IgE level
- increased IgG level
- increased IgG1 level
- increased IgM level
- increased T cell apoptosis
- increased T cell number
- increased T cell proliferation
- increased activated T cell number
- increased autoantibody level
- increased circulating interferon-gamma level
- increased circulating interleukin-10 level
- increased circulating interleukin-4 level
- increased circulating interleukin-5 level
- increased circulating interleukin-6 level
- increased circulating tumor necrosis factor level
- increased dendritic cell number
- increased eosinophil cell number
- increased inflammatory response
- increased leukocyte cell number
- increased lymphocyte cell number
- increased mean corpuscular volume
- increased mean platelet volume
- increased monocyte cell number
- increased regulatory T cell number
- increased sensitivity to induced morbidity/mortality
- increased spleen red pulp amount
- increased spleen weight
- increased spleen white pulp amount
- increased susceptibility to autoimmune disorder
- increased susceptibility to type IV hypersensitivity reaction
- intermingled spleen red and white pulp
- jaundice
- lethality at weaning complete penetrance
- lethargy
- liver inflammation
- lung inflammation
- lymph node inflammation
- male infertility
- melena
- multifocal hepatic necrosis
- narrow eye opening
- no abnormal phenotype detected
- orthokeratosis
- pale kidney
- pale liver
- parakeratosis
- pleural effusion
- poikilocytosis
- polychromatophilia
- postnatal growth retardation
- postnatal lethality
- postnatal lethality complete penetrance
- premature death
- respiratory system inflammation
- salivary gland inflammation
- scaly ears
- scaly skin
- short perineum
- skin inflammation
- skin lesions
- small ears
- small gonad
- small testis
- small thymus
- stomach inflammation
- thick ears
- thrombocytopenia
- thymus hypoplasia
- tight skin
- weight loss
role in cell
- expression in
- activity
- activation
- production in
- growth
- quantity
- proliferation
- transcription in
- number
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Foxp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-10 production
- transcription from RNA polymerase II promoter
- CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
- T cell homeostasis
- negative regulation of chronic inflammatory response
- inflammatory response
- tolerance induction to self antigen
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- isotype switching to IgE isotypes
- negative regulation of interferon-gamma production
- negative regulation of tumor necrosis factor production
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of immature T cell proliferation in thymus
- negative regulation of interleukin-6 production
- positive regulation of transforming growth factor beta1 production
- negative regulation of interleukin-4 production
- negative regulation of interleukin-5 production
- negative regulation of T cell cytokine production
- regulatory T cell differentiation
- negative regulation of T-helper 17 cell differentiation
- negative regulation of isotype switching to IgE isotypes
- negative regulation of CD4-positive, alpha-beta T cell proliferation
- negative regulation of defense response to virus
- positive regulation of interleukin-4 production
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
- establishment of endothelial blood-brain barrier
- negative regulation of CREB transcription factor activity
- negative regulation of cell proliferation
- T cell activation
- myeloid cell homeostasis
- response to virus
- positive regulation of transcription from RNA polymerase II promoter
- immature T cell proliferation in thymus
- positive regulation of peripheral T cell tolerance induction
- positive regulation of regulatory T cell differentiation
- negative regulation of transcription from RNA polymerase II promoter
- T cell mediated immunity
- chromatin remodeling
- negative regulation of interleukin-2 production
- regulation of isotype switching to IgG isotypes
- CD4-positive, alpha-beta T cell proliferation
- transforming growth factor beta1 production
- negative regulation of immune response
- negative regulation of interleukin-17 production
- T cell receptor signaling pathway
- regulation of transcription, DNA-dependent
- negative regulation of activated T cell proliferation
- T cell anergy
- B cell homeostasis
- regulation of transcription from RNA polymerase II promoter
- regulation of T cell anergy
- positive regulation of T cell anergy
- negative regulation of T cell proliferation
- response to lipopolysaccharide
- negative regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone acetyltransferase binding
- protein homodimerization activity
- histone deacetylase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- NF-kappaB binding
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- transcription corepressor activity
- metal ion binding
- NFAT protein binding