Rap1a Gene Summary [Mouse]
Enables GTPase activity and small GTPase binding activity. Involved in positive regulation of vasculogenesis. Acts upstream of or within several processes, including negative regulation of synaptic vesicle exocytosis; positive regulation of ERK1 and ERK2 cascade; and small GTPase-mediated signal transduction. Located in several cellular components, including cell junction; neuron projection; and sperm midpiece. Part of guanyl-nucleotide exchange factor complex. Is expressed in brain; early conceptus; eye; hemolymphoid system gland; and oocyte. Orthologous to human RAP1A (RAP1A, member of RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rap1a |
| Official Name | RAS-related protein 1a [Source:MGI Symbol;Acc:MGI:97852] |
| Ensembl ID | ENSMUSG00000068798 |
| Bio databases IDs | |
| Aliases | RAS-related protein 1a |
| Synonyms | AI848598, C21KG, G-22K, KREV-1, RAP1, RAP1A, member of RAS oncogene family, RAS-related protein 1a, SMGP21 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rap1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- enzyme binding
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- binding protein
- small GTP-binding protein domain
- guanyl-nucleotide exchange factor
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Rap1a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- Bladder Cancer Signaling
- Cancer Drug Resistance By Drug Efflux
- Chemokine Signaling
- CNTF Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- ErbB4 Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- Oncostatin M Signaling
- PPAR Signaling
- Prolactin Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Thyroid Cancer Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- breast cancer
- melanoma
- melanoma cancer
- schizophrenia
- vascular leak syndrome
- Crohn disease
- glomerulosclerosis
- Moyamoya disease
- macrothrombocytopenia
role in cell
- recruitment
- trafficking
- apoptosis
- expression in
- activation in
- phosphorylation in
- quantity
- adhesion
- migration
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- glutaminergic synapse
- cell junction
- cell periphery
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- specific granule membrane
- cytosol
- endosomal membrane
- chromosome
- sperm midpiece
- neurites
- early endosomes
- late endosomes
- membrane rafts
- phagosomes
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rap1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nervous system development
- establishment of endothelial barrier
- positive regulation of GTPase activity
- positive regulation of protein kinase activity
- cellular response to cAMP
- positive regulation of ERK1 and ERK2 cascade
- microvillus assembly
- positive regulation of vasculogenesis
- positive regulation of neuron projection development
- synaptic vesicle exocytosis
- Rap protein signal transduction
- protein localization in plasma membrane
- negative regulation of synaptic vesicle exocytosis
Cellular Component
Where in the cell the gene product is active
- late endosome
- neuron projection
- plasma membrane
- early endosome
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- anchoring junction
- sperm midpiece
- cytoplasm
- cytosol
- cell junction
- guanyl-nucleotide exchange factor complex
- endosome membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- guanyl-nucleotide exchange factor activity
- GDP binding
- small GTPase binding