Hk2 Gene Summary [Mouse]
Enables hexokinase activity. Involved in negative regulation of mitochondrial membrane permeability and negative regulation of reactive oxygen species metabolic process. Acts upstream of or within several processes, including carbohydrate phosphorylation; cellular response to leukemia inhibitory factor; and regulation of D-glucose import. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in obesity and type 2 diabetes mellitus. Orthologous to human HK2 (hexokinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hk2 |
| Official Name | hexokinase 2 [Source:MGI Symbol;Acc:MGI:1315197] |
| Ensembl ID | ENSMUSG00000000628 |
| Bio databases IDs | |
| Aliases | hexokinase 2 |
| Synonyms | HEXOKINASE 2, Hexokinase ii, HKII, HXK2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- mitochondrial presequence
- mitochondrial binding domain
- ATP binding
- glucose binding
- PLN02914
- glucokinase
- protein binding
- fructokinase
- hexokinase
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Hk2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- squamous cell lung cancer
- metastasis
- cutaneous melanoma
- mixed endometrioid serous endometrial cancer
- lymphomagenesis
- sarcoma
- hepatocellular carcinoma
- liver cancer
role in cell
- expression in
- binding in
- apoptosis
- growth
- cell death
- proliferation
- binding
- phosphorylation in
- migration
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- sarcoplasmic reticulum
- centrosome
- Mitochondria
- cytosol
- mitochondria-associated membranes
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mitochondrial membrane permeability
- glycolysis
- fructose 6-phosphate metabolic process
- lactation
- regulation of glucose import
- carbohydrate phosphorylation
- glucose metabolic process
- positive regulation of angiogenesis
- glucose 6-phosphate metabolic process
- response to ischemia
- apoptotic mitochondrial changes
- response to hypoxia
- cellular glucose homeostasis
- maintenance of protein location in mitochondrion
- establishment of protein localization in mitochondrion
- negative regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- centrosome
- sarcoplasmic reticulum
- intracellular membrane-bounded organelle
- membrane
- mitochondrion
- cytosol
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- glucose binding
- ATP binding
- protein binding
- glucokinase activity
- hexokinase activity
- fructokinase activity