Target List
Covers all exons in all known transcripts of targeted genes based on the Human GRCh38 genome build
Adenocarcinomas
APC, ATM, AXIN2, BMPR1A (ALK3), BRAF, BRCA1, BRCA2, CHEK2 (RAD53), EP300, FLCN, MLH1, MLH3, MSH2, MSH3, MSH6, MUTYH, NRAS, PALB2, PMS1, PMS2, POLD1, POLE, PTEN, RNF43, SMAD4 (MADH4), STK11 (LKB1), TGFBR2, TP53 (p53)
Colorectal Cancer Susceptibility
CCND1, GALNT12, POLD1, POLE, SMAD7
Familial Adenomatous Polyposis
APC, MSH3, MUTYH, NTHL1, POLD1, POLE
Hereditary Mixed Polyposis Syndrome
BMPR1A (ALK3), GREM1
Hereditary Nonpolyposis
BRAF, EPCAM, MLH1, MLH3, MSH2, MSH6, PMS1, PMS2, TGFBR2
Hereditary Polyposis Syndrome
BMPR1A (ALK3), GREM1
Juvenile Polyposis Syndrome
BMPR1A (ALK3), SMAD4 (MADH4)
Lynch Syndrome
BRAF, EPCAM, MLH1, MLH3, MSH2, MSH6, PMS1, PMS2, TGFBR2
Metastatic Colorectal Cancers
ATM, BRAF, NRAS
Muir-Torre Syndrome
MLH1, MSH2
Other Colorectal Cancer Genes
AURKA, BLM, CDH1 (E-Cadherin), PKHD1, PLA2G2A, RB1, RPS20, SEMA4A, TLR2, XRCC2