XRCC2 Gene Summary [Human]
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | XRCC2 |
| Official Name | X-ray repair cross complementing 2 [Source:HGNC Symbol;Acc:HGNC:12829] |
| Ensembl ID | ENSG00000196584 |
| Bio databases IDs | |
| Aliases | X-ray repair cross complementing 2, RAD51-like |
| Synonyms | 4921524O04Rik, 8030409M04Rik, FANCU, LOC102553514, POF17, RAD51, RecA, RGD1564823, SPGF50, X-ray repair complementing defective repair in Chinese hamster cells 2, X-ray repair cross complementing 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human XRCC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- walker type A motif
- DNA secondary structure binding
- Rad51
- enzyme
- protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- AAA domain
Pathways
Biological processes and signaling networks where the XRCC2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- lymphomagenesis
- non-Hodgkin disease
- hematologic cancer
- lymphoid cancer
- hematological neoplasia
- lymphatic neoplasia
role in cell
- formation
- apoptosis
- cell death
- survival
- growth
- molecular cleavage in
- development
- early S phase
- exchange
- sister chromatid exchange
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- centrosome
- nuclear foci
- nucleoplasm
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human XRCC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- DNA repair
- response to X-ray
- centrosome cycle
- double-strand break repair via homologous recombination
- neurogenesis
- strand invasion
- mitotic cell cycle
- negative regulation of neuron apoptotic process
- meiotic cell cycle
- in utero embryonic development
- somitogenesis
- positive regulation of neurogenesis
- response to gamma radiation
- regulation of fibroblast apoptotic process
Cellular Component
Where in the cell the gene product is active
- replication fork
- Rad51B-Rad51C-Rad51D-XRCC2 complex
- centrosome
- cytoplasm
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- four-way junction DNA binding