YKT6 Gene Summary
This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq, Jul 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | YKT6 |
| Official Name | YKT6 v-SNARE homolog [Source:HGNC Symbol;Acc:HGNC:16959] |
| Ensembl ID | ENSG00000106636 |
| Bio databases IDs | |
| Aliases | YKT6 v-SNARE homolog, R-SNARE |
| Synonyms | 0610042I15Rik,1810013M05Rik,YKT6 v-SNARE homolog,YKT6 v-SNARE homolog (S. cerevisiae) |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulated-SNARE-like domain
- SNAP receptor
- protein-cysteine S-palmitoleyltransferase
- enzyme
- protein binding
- SNARE motif
- Longin-like domains
Pathways
Biological processes and signaling networks where the YKT6 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- breast cancer
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- prostate cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- gastric adenocarcinoma
- gastric epithelial cancer
- chromophobe renal cell carcinoma
role in cell
- synthesis in
- fragmentation
- fusion
- assembly
- fusion in
- targeting
- autophagic flux in
- docking
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi-enriched fraction
- membrane fraction
- cellular membrane
- cell cortex
- Plasma Membrane
- endosomes
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- medial face of the Golgi apparatus
- Golgi membrane
- transport vesicles
- perikaryon
- dendrites
- apical processes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the YKT6 gene, providing context for its role in the cell.
biological PROCESS
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- membrane fusion
- vesicle targeting
- vesicle docking involved in exocytosis
- protein transport
- retrograde transport, endosome to Golgi
cellular COMPONENT
Where in the cell the gene product is active
- Golgi apparatus
- Golgi membrane
- endoplasmic reticulum
- neuronal cell body
- plasma membrane
- cytoplasmic vesicle membrane
- endosome
- cytoplasm
- mitochondrion
- SNARE complex
- cytosol
- transport vesicle
- endoplasmic reticulum-Golgi intermediate compartment membrane
molecular FUNCTION
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- cadherin binding
- SNAP receptor activity