STX6 Gene Summary [Human]
Enables syntaxin binding activity. Involved in several processes, including Golgi ribbon formation; retrograde transport, endosome to Golgi; and vesicle fusion. Acts upstream of or within endocytic recycling. Located in several cellular components, including early endosome; perinuclear region of cytoplasm; and trans-Golgi network. Part of SNARE complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | STX6 |
| Official Name | syntaxin 6 [Source:HGNC Symbol;Acc:HGNC:11441] |
| Ensembl ID | ENSG00000135823 |
| Bio databases IDs | |
| Aliases | syntaxin 6 |
| Synonyms | 2310039E05Rik, 2410005I16Rik, LOC102724791, Syn6, syntaxin 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STX6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Syntaxin 6, N-terminal
- cytoplasmic domain
- N-terminal domain of syntaxin-6 and similar proteins
- membrane attachment signal
- Helical region found in SNAREs
- protein binding
- cytosolic tail domain
- SNARE motif
- transporter
- syntaxin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- neoplasia
- non-insulin-dependent diabetes mellitus
- hepatocellular carcinoma
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- organismal death
- metastasis
role in cell
- binding in
- migration
- expression in
- proliferation
- apoptosis
- cell viability
- invasiveness
- fusion
- adhesion
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- raft fractions
- Golgi-endosome fractions
- golgi/trans-golgi network-rich vesicle fraction
- Golgi-enriched fraction
- membrane fraction
- synaptic vesicle membrane
- perinuclear Golgi regions
- cell surface
- perinuclear region
- intracellular membranes
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- Golgi Apparatus
- cytosol
- microsome
- Golgi membrane
- trans Golgi network
- endosomal compartment
- nucleoplasm
- synaptic vesicles
- recycling endosomes
- early endosomes
- clathrin-coated vesicles
- phagosomes
- immature secretory granules
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STX6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle fusion
- regulation of protein localization
- vesicle docking
- synaptic vesicle to endosome fusion
- intracellular protein transport
- retrograde transport, endosome to Golgi
- Golgi vesicle transport
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- phagocytic vesicle
- Golgi membrane
- Golgi apparatus
- plasma membrane
- nucleoplasm
- trans-Golgi network
- early endosome
- perinuclear region of cytoplasm
- endomembrane system
- SNARE complex
- cytosol
- recycling endosome
- recycling endosome membrane
- synaptic vesicle membrane
- clathrin-coated vesicle
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- syntaxin binding
- SNAP receptor activity
- SNARE binding