Gabrg2 Gene Summary [Rat]
Enables GABA-A receptor activity and chloride channel activity. Contributes to GABA receptor activity. Involved in several processes, including GABAergic synaptic transmission; cellular response to zinc ion; and response to anesthetic. Located in cell surface; dendrite membrane; and inhibitory synapse. Part of GABA receptor complex. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic specialization membrane. Biomarker of fetal alcohol spectrum disorder and hepatic encephalopathy. Human ortholog(s) of this gene implicated in alcohol dependence; alcoholic liver cirrhosis; amphetamine abuse; brain disease (multiple); and heroin dependence. Orthologous to human GABRG2 (gamma-aminobutyric acid type A receptor subunit gamma2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabrg2 |
| Official Name | gamma-aminobutyric acid type A receptor gamma 2 subunit [Source:RGD Symbol;Acc:61966] |
| Ensembl ID | ENSRNOG00000003241 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid type A receptor gamma 2 subunit |
| Synonyms | CAE2, DEE74, ECA2, EIEE74, FEB8, GABAA-R, GABA A receptor G2, Gaba A receptor γ-2, GABAAR gamma 2, GABAAR γ 2, gamma2, gamma-aminobutyric acid type A receptor subunit gamma 2, gamma-aminobutyric acid type A receptor, subunit gamma 2, GEFSP3, γ-aminobutyric acid type A receptor subunit gamma2, γ-aminobutyric acid type A receptor subunit γ 2, γ-aminobutyric acid type A receptor, subunit γ 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gabrg2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- extracellular domain
- intracellular loop
- inhibitory extracellular ligand-gated ion channel
- transmembrane helix kinks
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- benzodiazepine receptor
- ion channel
- GABA receptor
- anion channel
- LGIC_ECD
- neurotransmitter receptor
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- chloride channel
- transmembrane domain
- ligand-gated ion channel
- intracellular domain
- loop domain
Pathways
Biological processes and signaling networks where the Gabrg2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- motor dysfunction
- rheumatoid arthritis
- fatigue
- lung cancer
- multidrug-resistant tuberculosis
- tuberculosis
- extensively drug-resistant tuberculosis
- diabetes mellitus
- cancer
- septic shock
role in cell
- quantity
- assembly
- number
- loss
- inhibition
- hyperpolarization
- response by
- excitability
- rebound potentiation in
- rebound potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- cell surface
- intracellular space
- perisynaptic region
- cellular membrane
- postsynaptic membrane
- synaptic membrane
- dendritic spines
- synaptosomes
- synapse
- axons
- dendrites
- axon terminals
- presynaptic terminals
- inhibitory synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gabrg2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- cellular response to histamine
- post-embryonic development
- synaptic transmission, GABAergic
- adult behavior
- gamma-aminobutyric acid signaling pathway
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- dendrite membrane
- cytoplasmic vesicle membrane
- synapse
- neuron projection
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- GABA-A receptor activity
- neurotransmitter receptor activity
- chloride channel activity
- benzodiazepine receptor activity
- GABA-gated chloride ion channel activity