Gabra4 Gene Summary [Rat]
Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and inhibitory synapse assembly. Predicted to act upstream of or within central nervous system development. Is active in GABA-ergic synapse and postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human GABRA4 (gamma-aminobutyric acid type A receptor subunit alpha4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gabra4 |
| Official Name | gamma-aminobutyric acid type A receptor alpha4 subunit [Source:RGD Symbol;Acc:621670] |
| Ensembl ID | ENSRNOG00000002336 |
| Bio databases IDs | |
| Aliases | gamma-aminobutyric acid type A receptor alpha4 subunit |
| Synonyms | GABAA receptor alpha4, gamma-aminobutyric acid type A receptor subunit alpha 4, γ-aminobutyric acid type A receptor subunit alpha4, γ-aminobutyric acid type A receptor subunit α 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Gabra4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GABA-A receptor
- LGIC_ECD
- neurotransmitter receptor
- Neurotransmitter-gated ion-channel transmembrane region
- transmembrane domain of Cys-loop neurotransmitter-gated ion channels
- channel/pore class transporter
- Neurotransmitter-gated ion-channel ligand binding domain
- intracellular M3-M4 domain
- extracellular ligand-gated ion channel
- Cation transporter family protein
- benzodiazepine receptor
- ion channel
Pathways
Biological processes and signaling networks where the Gabra4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HIV infection
- nausea and vomiting
- infection
- cirrhosis
- critical illness
- metastatic gastric cancer
- gastric cancer
- acute respiratory distress syndrome
- schizophrenia
- lung cancer
regulates
- GABA-A receptor
- GABRA4
- chloride
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perisynaptic region
- somatodendritic region
- cellular membrane
- synaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Gabra4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of postsynaptic membrane potential
- synaptic transmission, GABAergic
- gamma-aminobutyric acid signaling pathway
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- dendrite membrane
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GABA-A receptor activity
- chloride channel activity
- benzodiazepine receptor activity
- GABA-gated chloride ion channel activity