Pygo1 Gene Summary [Mouse]
Predicted to enable methylated histone binding activity. Involved in canonical Wnt signaling pathway. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; positive regulation of transcription by RNA polymerase II; and spermatid nucleus differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; heart; male reproductive system; pancreas; and urinary system. Orthologous to human PYGO1 (pygopus family PHD finger 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pygo1 |
| Official Name | pygopus 1 [Source:MGI Symbol;Acc:MGI:1919385] |
| Ensembl ID | ENSMUSG00000034910 |
| Bio databases IDs | |
| Aliases | pygopus 1 |
| Synonyms | 2600014C22Rik, LOC100506346, LOC283658, LOC678949, pygopus 1, pygopus family PHD finger 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pygo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- protein binding activity, bridging
- PHD finger superfamily
- protein binding
Pathways
Biological processes and signaling networks where the Pygo1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- exencephaly
- cleft lip
- aphakia
role in cell
- expression in
- differentiation
- development
- inactivation
- inactivation in
- differentiation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pygo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- kidney development
- spermatid nucleus differentiation
- canonical Wnt receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- protein localization to nucleus
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- methylated histone residue binding