Orc6 Gene Summary [Mouse]

Predicted to enable DNA binding activity. Acts upstream of or within DNA-templated DNA replication. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in several structures, including brain ventricular layer; early conceptus; jaw; liver lobe; and submandibular gland primordium. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 3. Orthologous to human ORC6 (origin recognition complex subunit 6). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Orc6
Official Name
origin recognition complex, subunit 6 [Source:MGI Symbol;Acc:MGI:1929285]
Ensembl ID
ENSMUSG00000031697
Bio databases IDs NCBI: 56452 Ensembl: ENSMUSG00000031697
Aliases origin recognition complex, subunit 6
Synonyms 6720420I10Rik, ORC6L, origin recognition complex subunit 6, origin recognition complex, subunit 6
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Orc6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Middle domain of the origin recognition complex subunit 6
  • protein binding

Pathways

Biological processes and signaling networks where the Orc6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hepatocellular carcinoma
  • liver cancer
  • epithelial cancer
  • Meier-Gorlin syndrome type 3
  • lung adenocarcinoma
  • lung adenocarcinoma formation
  • organismal death
  • osteosarcoma
  • osteosarcomagenesis
  • colorectal cancer
regulated by
regulates
role in cell
  • formation
  • morphology
  • mitosis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • chromatin fraction
  • fibrillar center
  • cell periphery
  • midbody
  • Flemming body
  • cytosol
  • chromosome
  • nucleoplasm
  • cleavage furrow
  • kinetochores
  • centromeres

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Orc6 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • DNA-dependent DNA replication initiation

Cellular Component

Where in the cell the gene product is active
  • origin recognition complex
  • nucleus
  • membrane
  • cytosol
  • nuclear origin of replication recognition complex
  • fibrillar center
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • DNA binding
  • protein binding

Gene-Specific Assays for Results You Can Trust

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