Nek7 Gene Summary [Mouse]
Enables molecular function activator activity. Involved in cellular response to potassium ion and positive regulation of NLRP3 inflammasome complex assembly. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Orthologous to human NEK7 (NIMA related kinase 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nek7 |
| Official Name | NIMA (never in mitosis gene a)-related expressed kinase 7 [Source:MGI Symbol;Acc:MGI:1890645] |
| Ensembl ID | ENSMUSG00000026393 |
| Bio databases IDs | |
| Aliases | NIMA (never in mitosis gene a)-related expressed kinase 7 |
| Synonyms | 2810460C19RIK, NIMA (never in mitosis gene a)-related expressed kinase 7, NIMA-related kinase 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nek7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
- activation loop
- zDHHC ankyrin repeat binding domain
Pathways
Biological processes and signaling networks where the Nek7 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- chronic obstructive pulmonary disease
- breast cancer
- major depression
- melanoma
- melanoma cancer
- esophageal adenocarcinoma
- esophageal carcinoma formation
- colorectal cancer
- growth failure
role in cell
- cell death
- quantity
- expression in
- apoptosis
- growth
- survival
- formation
- activation in
- mitosis
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- microtubule organizing centers
- nucleoplasm
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nek7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of telomerase activity
- spindle assembly
- positive regulation of telomere maintenance via telomerase
- positive regulation of NLRP3 inflammasome complex assembly
- protein phosphorylation
- peptidyl-serine phosphorylation
- regulation of mitotic cell cycle
- cellular response to potassium ion
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- microtubule organizing center
- cytoplasm
- spindle pole
- nucleoplasm
- microtubule
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity