Lhx4 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Acts upstream of or within several processes, including negative regulation of apoptotic process; neuron differentiation; and placenta development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in combined pituitary hormone deficiency 4. Orthologous to human LHX4 (LIM homeobox 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lhx4 |
| Official Name | LIM homeobox protein 4 [Source:MGI Symbol;Acc:MGI:101776] |
| Ensembl ID | ENSMUSG00000026468 |
| Bio databases IDs | |
| Aliases | LIM homeobox protein 4 |
| Synonyms | A330062J17Rik, CPHD4, Gsh-4, LIM homeobox 4, LIM homeobox protein 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lhx4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- double-stranded DNA binding
- methyl-CpG binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoplasia
- atelectasis
- acute myeloid leukemia
- combined pituitary hormone deficiency-4
role in cell
- expansion
- number
- differentiation
- apoptosis
- cell death
- guidance
- abnormal morphology
- specification
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular space
- nuclear foci
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lhx4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- medial motor column neuron differentiation
- motor axon guidance
- neuron differentiation
- negative regulation of apoptotic process
- apoptotic process
- placenta development
- positive regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- methyl-CpG binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity